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Allopurinol (Zyloprim) 300 mg Price & Gout Treatment Benefits
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Allopurinol 300 mg Price Per Pill: A Comprehensive Guide
Searching for allopurinol 300 mg price per pill or buy allopurinol 300 mg online? You're not alone. Allopurinol is a widely sought-after medication for managing hyperuricemia and gout, and understanding its cost and availability is crucial for patients. The price of allopurinol 300 mg per pill varies globally, influenced by factors like region, pharmacy type, and brand vs. Generic status. In the UK, prices typically range from £0.10 to £0.50 per pill when purchased through licensed pharmacies, while international online suppliers may offer lower rates. To buy allopurinol 300 mg cheaply, consumers often compare prices across platforms, prioritising affordability without compromising quality.
Active Ingredient Analogues & Advantages of Allopurinol
Allopurinol's active ingredient, allopurinol, belongs to the xanthine oxidase inhibitor class. Key analogues include:
1. Febuxostat: A non-purine inhibitor with comparable efficacy but higher cost. Allopurinol remains more affordable and extensively studied for long-term use.
2. Probenecid: A uricosuric agent that increases uric acid excretion. Unlike allopurinol, it is less effective in severe renal impairment.
3. Lesinurad: Combines with xanthine oxidase inhibitors for enhanced uric acid reduction but carries a higher risk of kidney-related adverse effects.
4. Pegloticase: An intravenous enzyme therapy for refractory gout. Allopurinol is preferred for oral administration and routine management.
5. Topiroxostat: A newer Japanese-developed inhibitor with similar mechanisms but limited global availability.
Allopurinol's advantages include proven safety over decades, broad prescribing experience, and suitability for patients with moderate renal dysfunction. Its cost-effectiveness makes it a first-line therapy in guidelines, unlike newer, pricier alternatives.
Medical Uses of Allopurinol
Allopurinol is prescribed for chronic uric acid overproduction, addressing conditions such as:
- Gout: Prevents acute flares by lowering serum urate levels, reducing tophi formation, and mitigating joint damage.
- Hyperuricemia: Manages elevated uric acid due to metabolic syndromes, chemotherapy, or genetic predispositions (e.G., Lesch-Nyhan syndrome).
- Urate Nephropathy: Prevents kidney stone formation in patients with recurrent calculi linked to hyperuricosuria.
- Tumor Lysis Syndrome: Administered prophylactically during aggressive cancer treatments to avert acute kidney injury from rapid cell breakdown.
Its mechanism involves inhibiting xanthine oxidase, diverting purine metabolism to produce less insoluble uric acid. This foundational role in uric acid management solidifies its status as a cornerstone in rheumatology and nephrology.
Is Allopurinol Right for Me?
Determining if allopurinol suits your needs depends on several factors:
- Gout Sufferers: If you experience recurrent gout attacks (more than two annual episodes), allopurinol is a first-line preventative. Start with low doses (100 mg daily), titrating upward to avoid flare-ups during uric acid mobilisation.
- Kidney Stone Formers: Those with calcium oxalate or uric acid stones may benefit, especially if hyperuricosuria is confirmed. Ensure adequate hydration to complement therapy.
- Cancer Patients: Chemotherapy-induced tumor lysis syndrome risk warrants prophylactic use, often at higher doses (600–800 mg daily) under close monitoring.
- Renal Impairment: Dosage adjustments are necessary for eGFR <60 mL/min, but allopurinol remains safer than alternatives like febuxostat in advanced CKD.
- Allergy Concerns: Cross-reactivity with aminophylline or other purine derivatives may contraindicate use. Hypersensitivity reactions (e.G., Stevens-Johnson syndrome) are rare but serious.
Consult a healthcare provider to evaluate your medical history, concurrent medications (e.G., azathioprine, which interacts with allopurinol), and renal function. While buying allopurinol 300 mg is straightforward, personalised dosing and monitoring ensure optimal outcomes. For those prioritising cost and evidence-based efficacy, allopurinol often outweighs newer, costlier options, provided individual risk factors are managed. Always verify supplier credibility when purchasing online to avoid counterfeit products.
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