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Opioids like OPANA ER may be provided to patients who are more vulnerable, but in these cases, its use requires close monitoring for signs of addiction, abuse, and misuse in addition to comprehensive counseling regarding the hazards and appropriate usage of the medication. It is not recommended to use this medication "as needed" or to alleviate occasional pain. Long-term usage of oxymorphone has the potential to become a habit (creating mental or physical dependence).